It has been suggested that “inflamm-aging” is due to immune exhaustion which is associated with reduced effector functions and increased expression of inhibitory receptors (IRs). Thus, Belkina et al.,
News
Does BCG improve de novo malaria immunity ?
There is limited research on the impact of BCG on malaria. Murine models have shown that BCG reduces parasitaemia in mice compared to controls. Researchers aimed to provide...
Hematopoietic stem cell transplantation cures HIV
Study by Gupta et al., reports for the second time, that HIV can be cured by using allogeneic stem cell transplantation from a donor that has a homozygous genetic deletion...
Do neutrophils play a role in age-associated increase in flu mortality?
Influenza virus infection causes more mortality in elderly compared to younger people, and one of the main reasons could be aging of the immune system. Aging impairs both innate ...
Do NK cells play a role in vaccine induced humoral immunity ?
Natural killers cells (NKs) are one of the first responders and mediators of inflammation. However, their exact role in vaccine induced immunity is not adequately defined.
ICOS: is it essential for Treg-IL10 expression in the colon?
anduyt et al., aimed to determine the role of ICOS signalling of Tregs and expression of IL-10 in the colons of mice. As expected ICOS knock out (KO) mice compared to wild type...
How does IL-27 attenuate autoimmune neuroinflammation?
Researchers are currently exploring the potential use of IL-27 as an immunotherapeutic agent. An example of this, is the experimental administration...
CNS-neuroinflammation: not all myeloid cells are responsible
The central nervous system (CNS) is largely considered as an immune privileged site. Recently, this school of thought has been shown to be nuanced...
Immunosenescence: how does it affect vaccine Ab responses ?
Researchers (Henry et al.,) aimed to determine how “ageing” affects influenza vaccine responses. They focused on flu-vaccine responses, as the highest adult flu...
Recurrent Strep throat: when TFH cells “turn on” you
Recurrent episodes of strep throat are particularly common in children, where some develop recurrent tonsillitis (RT). Why some children develop GAS RT and what immunological features...