Evidence from a murine model of mycetoma suggests that IL-17 producing T cells, termed Th17 cells may play a role in mycetoma pathogenesis. IL-17 is a pro-inflammatory cytokine which can play a role in tissue inflammation and can indirectly contribute to neutrophil infiltration.
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How does plasmodial hemozoin contribute to cerebral malaria pathogenesis?
Phagocytic ingestion of hemozoin results in production of pro-inflammatory cytokines and reactive oxygen species (ROS), thus suggesting a potential mechanism of hemozoin induced immuno-pathogenesis. Rualf et al., used...
Are neutrophils in the tumor microenvironment friend or foe?
Neutrophils have been implicated in tumor pathology, where studies have reported a positive association between high neutrophil levels and tumor progression. Researchers from Europe (Ponzetta et al.,) aimed to determine...
Animal models to measure mucosal innate immunity: zebrafish vs mice.
The use of an inappropriate animal model that is not similar to human pathology or disease progression can slow the development of new therapeutics. Progatzky et al., aimed to compare respiratory mucosal innate immune...
Development of natural murine model of Cryptosporidiosis
Developing a murine model that recapitulates human infection is challenging. Sateriale et al., aimed to develop a murine model of Cryptosporidiosis that is similar to human infection and can be used to test potential vaccine strategies.
Does whole cell pertussis vaccination skew infection induced Ab profiles?
Raeven et al., conducted an in-depth profiling of Ab repertoire following a pertussis episode in adolescents and young adults with a specific focus on determining the effect of vaccine priming in infancy on subsequent...
Is Yellow fever vaccination safe for HIV+ individuals?
Previous studies have demonstrated variable safety outcomes of yellow fever vaccinated HIV+ individuals. Thus, Colin de Verdiere et al., conducted a safety trial to determine the safety and immunogenicity of profile of YFV...
The emerging role of IL-26 in fighting against intracellular microbes
Dang et al., utilised the human leprosy model to showcase the ability of IL-26 to provide protection against intracellular bacteria. This research opens up the possibility for Th17 cells to also participate in immune...
T cell activation as a potential surrogate marker for TB treatment efficacy.
Ahmed et al., assessed changes in phenotypic markers on MTB-specific CD4+ T cells in peripheral blood mononuclear cells (PBMC) of subjects with active TB from the start to the end of treatment and compared...
Does HIV-env vaccination strategy affect the recognition pattern of IgG responses?
Understanding the factors that influence the vaccine-induced IgG recognition of certain HIV Env regions might aid in an improved and targeted HIV vaccine design.To this end, Nadai et al., closely mapped the IgG response...