Sánchez-Reyes et al., evaluated the effect of supernatants from cerival cancer derived-cell lines on the phosphorylation of STAT1, NF-kb-p65 and STAT6 and the impact in the secretion profile of cytokines and growth factors by macrophages...
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How DNA outside cells can be targeted to prevent the spread of cancer
Study lead by Prof Ryushin Mizuta, have now discovered exactly how cfDNA is generated. They also talk about the applications of DNase1L3-the enzyme mainly responsible for generating cfDNA-as a novel molecule to prevent the spread of tumors.
Solving the puzzle of IgG4-related disease, the elusive autoimmune
Study lead by Prof. Masato Kubo, “planned to explore how IgG4 Abs contributes to the CTL-mediated pancreas tissue damage in IgG4-RD, and also to evaluate the pathogenic function of human IgG4 Abs using the mouse model that we have established.”
How the rice blast fungus “eats” its own cell wall to launch an attack
In response to environmental changes and nutrient starvation, cells are known to undergo extreme alterations. This includes switching from one type to another (“differentiation”) and changes in metabolic pathways (“metabolic switching”).
Can intravenous-BCG prevent M.tb infection ?
In this article, we highlight a recently published article by Darrah et al., which aimed to determine how dose and route of BCG vaccination influence the generation of systemic and tissue-resident immunity, as well as “protect” against TB. In their study, they vaccinated non-human primates...
How does group A Streptococcus evade immunity?
Wierzbicki et al., utilised Biomimetic Virulomics a nanotechnology-enabled affinity enrichment coupled with multiplexed quantitative proteomics platform to enrich red blood cell (RBC)-specific effector proteins secreted by GAS.
TB biomarker based on anti-Ag85B and 4 inflammatory molecules.
We report findings from a recently published article “A rapid triage test for active pulmonary tuberculosis in adult patients with persistent cough”(Ahmed et al., 2019).Ahmed et al., “hypothesized that a blood protein-based...
Immuno-Jaipur Highlight: Primary immunodeficiencies
In our final article about the proceedings of the Immuno-Jaipur course, we shall highlight talks given by faculty about their research on PIDS. Children with PIDs are often misdiagnosed for cancers due to have.
Immuno-Jaipur Highlight: Clinical viral immunity
This article highlights talks about viral immunity. Prof Gray presented his research on the impact of HIV on placental and fetal immunity, while Dr Groom presented on the importance of microscopic imaging in understanding viral immunity.
Immuno-Jaipur Highlight: MHC and Transplantation Immunology
The theme of the 5th and last day of Immuno-Jaipur was Clinical Immunology, which included talks from researchers that conduct translational research. In this article we shall highlight talks by Dr Narinder Mehra and Rajalingum Raja, who presented talks on Human Leukocyte Antigen (HLA) system immunology.