Researchers (Bosch et al.,) investigated the role of lipid droplets in innate immunity by utilising hepatic (liver) lipid droplets to study the role of these organelles in response to bacterial or lipopolysaccharide challenge. They measured lipid droplet size and co-localisation...
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Trained Immunity in Dogs.
Paris et al., investigate pro-inflammatory functions, using utilised ELISA, Luminex and flow cytometry , and also measured the activity of reactive oxygen species and phagocytosis by canine macrophages. Using an adapted in vitro experimental model of immune training, they confirmed that stimulation...
NIH COVID-19 lecture on SARS-CoV-2 neutralising antibodies
In a recent NIH COVID-19 SIG webinar, Prof. Paul Bieniasz presented research that demonstrated that monoclonal nAbs from convalescent patients have potential sterilising effect in vivo using a mouse-adapted SARS-CoV-2 pseudovirus model.
Why is flu vaccine induced immunity short-lived?
Davis et al., detected influenza-specific BMPCs and IgG/IgA Abs in volunteers before vaccination. This immunity was due to previous flu vaccination and flu episodes. New seasonal flu vaccination significantly...
Molecular mimicry: perfect match propels pathologies
Molecular mimicry drives the pathogenesis of autoimmune neuropathies such as Guillain-Barré syndrome and multiple sclerosis.Does molecular mimicry also play a role in COVID-19 pathogenesis?
SAIS/Immunopaedia Webinar: Immunothrombosis & COVID-19
We highlight SAIS/Immunopaedia COVID-19 Webinar featuring talks by haematopathologists Dr Susan Louw and A/Prof Jessica Olpie on immunothrombosis & COVID-19. Dr Susan Louw began her talk...
Safety and immunogenicity of the SARS-CoV-2 mRNA-1273 vaccine candidate in older age.
A follow-up article published in NEJM showed that the mRNA vaccine, mRNA-1273, was safe and immunogenic in older vaccine volunteers (56-70 years). The vaccine has also been shown to be safe and immunogenic in younger people.
Genetically modified Lactococcus lactis- A potential microbial therapeutic for acute colitis?
Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is a complex inflammatory disorder of the gastrointestinal tract. The incidence of IBD is on the rise worldwide and possible triggers of the disease include an inflammatory response ...
IUIS Webinar: Impairment of the immunological and neurological synapses by respiratory viruses
The last IUIS COVID-19 webinar featured a talk by Alexi Kalergis: Impairment of the immunological and neurological synapses by respiratory viruses and the implications for the design of vaccines.
Safety and immunogenicity of the Ad26.COV2.S COVID-19 vaccine candidate.
Recent medRxiv pre-print reports on an interim analysis of an adenovirus type 26 SARS-CoV-2 vaccine candidate (Ad26.COV2.S). This was a phase 1/2a randomized, double-blinded, placebo-controlled clinical study consisting of a non-replicating adenovirus 26 based vector...