The innate immune system has the ability to sense and respond to dead cells. Allowing the immune system to control non-infectious inflammatory responses. To better understand the mechanics of this process researchers from the University of Munich identified an inhibitory C-type lectin receptor, Clec12a, …
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Results from a novel flu vaccine
Influenza pandemics, such as the H1N1 (swine flu) outbreak in 2009...
Using immunomics to find vaccine antigens for schistosomiasis
Although schistosomiasis or bilharzia kills almost half a million people per year...
South African treatment guidelines should use viral load, not CD4 count for greater success
Fully suppressive HIV treatment greatly reduces the risk of HIV transmission...
T cell differentiation regulated by methyltransferase G9A during murine intestinal inflammation
Th cells differentiate into one of several effector lineages, including Th17, and Tregs...
Understanding molecular evolution of HIV and ART
Antiretroviral therapy (ART), although known to be effective for preventing the onset of AIDS does not cure HIV...
Inhibition of calcineurin abrogates whereas inhibition of mTOR promotes Regulatory T Cells
In order to control and attenuate both autoimmune responses of self-reactive...
Neuronal ferritin heavy chain and opiate abuse affect HIV-associated cognitive dysfunction
The chemokine CXCL12 and its cognate receptor CXCR4 perform multiple functions...
Agonistic induction of PPARy shown to reverse emphysema
Cigarette smoke is the most common cause of pulmonary emphysema, which results in an irreversible loss of lung structure and function. Lung myeloid dendritic cells (mDCs) derived from cigarette smokers activate autoreactive Th1 and Th17 immune responses and thus have been implicated in emphysema …
Treating rhematoid arthritis with peptide-specific CD8+ regulatory T cells
The autoimmune disorder rheumatoid arthritis (RA) is characterized by joint inflammatio...