17th November, 2017Boyle et al. showed that CD4+ IL-10 producing Pf-specific T cells are of Th1 origin and are associated with reduced parasitemia in children from a high malaria endemic country.This suggests a role of IL-10+ ...
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Is HIV becoming more resistant over time?
15th November, 2017Since the discovery of HIV in the 1980s, the virus has spread worldwide, causing the AIDS pandemic. Neutralising antibodies can bind to the virus and prevent it from entering into cells, however, there has been debate about whether HIV strains are...
Pre-diabetes associated M.tb-specific T cell dysfunction
13th November, 2017Kumar et al. showed that individuals with PDM-LTBI had significantly decreased CD4+ Th1 T cell functionality compared to LTBI only individuals. This dysfunction was...
Insight into immune activation caused by Ebola virus
10th November, 2017One of the hallmarks of Ebola virus (EBOV) infection is a heightened immune response characterized by a "cytokine storm". Researchers investigated the cause...
Highlights from the Infectious Disease (ID) Week 2017 Conference
8th November, 2017Infectious Disease (ID) Week, an annual conference which started in October 2012, has just completed its sixth meeting in San Diego, earlier in October 2017. Establishing itself as a...
Effect of BCG vaccination on HIV-exposed infants
6th November, 2017Large numbers of infants still get infected with HIV during breastfeeding. Understanding what increases the risk of infection in these infants may aid in a decrease...
Mechanism behind malaria-induced autoimmunity
3rd November, 2017 Plasmodium infection has been known to cause autoimmune anemia. Researchers have now uncovered the mechanism behind this. The team found that Plasmodium DNA was responsible for the...
Lung on a chip model recapitulates lung cancer pathology and therapy
1st November, 2017 Researchers from the Wyss Institute (Hassell et al) developed an in vitro orthotopic lung cancer model utilising the lung on a chip technology, which is able to...
Antibody cocktail to prevent Zika infection in pregnant women
30th October, 2017Zika virus (ZIKV) causes major complications to fetal development and therefore a ZIKV vaccine has become one of the main focuses of research groups around the world. Researchers have isolated three...
Antibody-drug dual combination to fight cancer
27th October, 2017Antibody-drug conjugates (ADCs) are therapeutics which combine drugs with highly antigen-specific antibodies. Currently, most of these conjugates are joined together...