13th July 2018 Tuberculosis (TB) is the leading cause of death due to infectious diseases worldwide. One of the approaches to end the TB epidemic is the development of efficacious vaccines against ...
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HIV vaccine induces similar responses in humans and rhesus macaques.
10th July 2018 One of the major challenges of developing a vaccine against HIV, is the extensive HIV strain diversity. One approach being ...
Ontogeny of MAITs
6th July 2018 Researchers from France, aimed to determine the postnatal expansion and maturation of MAITs from birth to adulthood using cross-sectional samples. Ben Youssef et al., predominantly defined MAITs as Vα7.2+ CD161high T cells, as the MR1-tetarmer ...
Public Antibody Clonotypes observed in HIV+ individuals.
3rd July 2018 A collaborative research project between researchers in South Africa and US, examined the antibody repertoire in HIV ...
Another use for BCG, potential Diabetes cure?
29th June 2018 Researchers conducted a phase 1 clinical trial where individuals were either vaccinated with two doses of BCG or placebo two weeks apart, followed by the standard of care type 1 diabetes treatment.
Can testosterone regulate B cell numbers?
28th June 2018 Sex steroids are known to have great effects on the immune system. Females are known to induce stronger immune responses to vaccination than males. Furthermore, Studies have shown that the prevalence of autoimmune disorders such as ...
Initial Immune Responses to TB in the Human Lung
26th June 2018 Early immune responses to pathogens in the lungs play a role in the clearance or establishment of an infection. Our understanding of immunity in the human lung has increased over time but is still limited ...
Antibody-based vaccine protects against 31% of HIV isolates
22nd June 2018 One of the goals in developing an effective, global HIV vaccine is to elicit potent antibodies, capable of neutralizing the majority of circulating HIV strains. These antibodies are known as ...
Natural infection improves breadth of vaccine induced memory
21st June 2018 Researchers from the University of Queensland in Australia, aimed to determine if vaccine induced J8-specific memory B cells are boosted upon infection ...
MGIAs: potential role of trained immunity ?
18th June 2018 Researchers led by Tom HM Ottenhof and Mihai Netea (Joosten et al., 2018), aimed to determine the effect of “trained immunity” on mycobacterial growth. Researchers focused on trained immunity, as recent studies have shown that ...