25th September, 2018 CD4 T cells, particularly those that express IFN-γ have been shown to be essential for control of Mycobacterium tuberculosis infection in both animal models and humans. However, numerous studies have shown that IFN-γ expression by CD4 T cells...
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Omentin-1 rescues inflammation-induced osteoporosis
19th September, 2018 Recent work by Shan-Shan Rao et. al, has highlighted the potential of Omentin-1 in downregulating the activity of proinflammatory cytokines, thereby unravelling its mechanism ...
New hope from chronic HBV patients: non-replicative Ad-HBV vaccine
14th September, 2018 Hepatitis B (HBV) remains a global health problem, with two billion people having serologic evidence of past or ongoing HBV infection.An estimated 257 million people, 3.5% of the global...
Have you heard of analytic treatment interruption of HIV ART?
12th September One of the goals for the HIV research field is to achieve a functional cure for HIV, the elimination of detectable virus without the use of ART. Clinical validation of new treatment options ...
A novel function of the antihelminthic drug Praziquantel: new strategy for combatting schistosomiasis
Interesting work by Chan and colleagues describes an unknown mechanism of action of the tetracyclic tetrahydroisoquinoline praziquantel (PZQ) the drug ...
What is the incubation period of TB?
5th September 2018 A recent Analysis by Behr et al., “Revisiting the timetable of tuberculosis”, highlights the need for improved understanding of the timeline of TB progression and its implications for TB elimination strategies. In this analysis article, Behr et al., discuss various longitudinal studies that illustrate that majority...
E-cigarettes may not be a healthier alternative to traditional cigarettes.
31st August 2018 A study conducted by Scott et al., utilized a novel method to develop e-cigarette vapour condensate that is physiologically similar to the vapour e-cigarette users are exposed to. Scott et al., demonstrated that e-cigarette vapour condensate ...
α4β7-MAdCAM interaction promotes HIV replication.
29th August 2018 Several studies with non-human primates (NHPs) have shown that in -vivo administration of an antibody against the integrin can induce persistent Simian immunodeficiency virus (SIV) control, delay disease progression, and reduce viral titres ...
Comparing H56 responses in NHP and humans using mathematical modelling.
26th August 2018 Researchers whom tested H56 candidate vaccine in NHPs and humans used mathematical modeling to compare vaccine induced immunity between these two species. H56 is a TB candidate vaccine that contains Mycobacterium tuberculosis (M.tb) antigens ...
Fatal SFTSV is associated with defective B cell responses
22nd August 2018 Severe Fever with Thrombocytopenia Syndrome (SFTS) is an emerging infectious disease with a 10-30% fatality rate. SFTS is caused by Phlebovirus (also referred to as SFTSV) and is predominantly transmitted by ticks ...