Influenza virus infection causes more mortality in elderly compared to younger people, and one of the main reasons could be aging of the immune system. Aging impairs both innate ...
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Do NK cells play a role in vaccine induced humoral immunity ?
Natural killers cells (NKs) are one of the first responders and mediators of inflammation. However, their exact role in vaccine induced immunity is not adequately defined.
ICOS: is it essential for Treg-IL10 expression in the colon?
anduyt et al., aimed to determine the role of ICOS signalling of Tregs and expression of IL-10 in the colons of mice. As expected ICOS knock out (KO) mice compared to wild type...
How does IL-27 attenuate autoimmune neuroinflammation?
Researchers are currently exploring the potential use of IL-27 as an immunotherapeutic agent. An example of this, is the experimental administration...
CNS-neuroinflammation: not all myeloid cells are responsible
The central nervous system (CNS) is largely considered as an immune privileged site. Recently, this school of thought has been shown to be nuanced...
Immunosenescence: how does it affect vaccine Ab responses ?
Researchers (Henry et al.,) aimed to determine how “ageing” affects influenza vaccine responses. They focused on flu-vaccine responses, as the highest adult flu...
Recurrent Strep throat: when TFH cells “turn on” you
Recurrent episodes of strep throat are particularly common in children, where some develop recurrent tonsillitis (RT). Why some children develop GAS RT and what immunological features...
TB episode following PD-1 blockade
Successful use of PD-1 blockade for cancer immunotherapy, has brought up the question as to whether this same therapy could be successful against infectious diseases such as tuberculosis (TB) and HIV.
Can a vaccine prevent ZIKV associated fetal abnormalities ?
Researchers from Germany aimed to determine whether measles-virus expressing Zika envelope protein E (MV-Zika-sE) sufficiently prevent...
Does mucosal BCG vaccination induce “protective” immunity ?
It is hypothesised that lung mucosal (muc-) BCG vaccination may overcome this pitfall by inducing robust mucosal immunity. Researchers from Netherlands aimed