Very few medical interventions compete with vaccines for their cumulative impact on global health. For this reason, the Jenner institute, University of Oxford and Pirbright started vaccinology courses in Africa, where global burden of vaccine preventable...
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Immunoinformatics Mexico 2019: Immunologic plasticity, defense lines.
"To maintain our homeostasis we need to constantly change and adapt to the environment," said Mariana Martínez Sánchez, during her presentation titled “Plasticity in the Immune System: From Model to Mechanisms” at Immunoinformatics 2019.
Immunoinformatics Mexico 2019: Part Two
Debora de Oliveira-Lopes explained the work-flow she utilises to identify epitopes for candidate for potential Schistosoma vaccines. She begins this process by selecting immunodominant epitopes that were identified by in-vitro antibodies (Ab) selection. She then reverse transcribes the amino-acid...
Immunoinformatics Mexico 2019: Part One
We shall share highlights of the first Latin-American Immuno-Informatics Course over the next series of articles. This course was attended with 36 participants and faculties from Africa and North & South America. To prepare regional scientists for the interdisciplinary Next Generation of Immunology,
Aiding Tuberculosis vaccine studies with the use of a mycobacterial growth inhibition assay
One of the major barriers to Tuberculosis vaccine development has been the lack of a correlate of protection or biomarker that can aid in the selection of vaccine candidates at early stages of the vaccine pipeline.
Further Support of the Emerging “Immunologic” Hypothesis in Mood and Eating Disorders
The brain and the immune system can communicate with each other in a few different ways. One way is through neural projections of the vagal and trigeminal nerves into different structures of the brain...
Immunopaedia goes to the XIII World Immune Regulation Meeting
From 6 to 9 April 2019, the XIII World Immune Regulation Meeting (WIRM) was hosted in Davos, Switzerland. The congress gathered top class worldwide researchers in basic and clinical immunology as well as eager students who presented their latest results on immune activation...
Evolution of flu-vaccine induced B cell responses
Matsude et al., examined “B cell expansion and evolution after vaccination with replication-competent flu vaccine expressing hemagglutinin (HA) H5 glycoprotein”. They studied both plasma (serum) HA-Ab levels as well as Abs generated from purified influenza-specific (HA) memory B...
Antiviral pathways induced in the RV144 vaccine trial
Gene set enrichment analysis of HIV-envelope stimulated PBMCs revealed that the RV144 vaccine induced genes associated with antigen presentation and antiviral functions. Specifically, Fourati et al., linked IFN-γ responses with reduced risk of HIV acquisition, while NFKB and mTOR...
How are CD8 responses against the malaria liver stage antigens primed ?
Induction of robust and in some cases sterilising CD8 T cell immunity against Plasmodium parasite requires Plasmodium sporozoite infection of hepatocytes, known as the malaria liver stage. As a result, researchers believe that whole cell malaria parasite vaccines...