Trypanosomiasis poses a serious threat to the agricultural economy. Treatment of the disease has severe side effects and currently no vaccine exists. Onyilagha et al., aimed to determine if NK cells play an important role during acute Trypanosomiasis.
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Are MAIT cells detectable in lymph?
It is unclear whether depletion of MAIT cells in the blood is due to apoptosis or migration to sites of infection, and whether MAIT cells in blood and tissue have distinct phenotypic and functional characteristics. Voillet et al., aimed to contribute to this knowledge gap by determining if MAIT cells...
Does S. mansoni treatment affect HIV susceptibility?
Yegorov et al., employed ex vivo HIV entry assays in combination with flow cytometry, cytokine measurements and transcriptome analysis to gain insight on how standard praziquantel schistosomiasis therapy affects systemic and genital immunology of Ugandan women.
Investigating the HIV viral reservoir during acute infection
CD4 TSCM and TCM cells are considered to play a major role in long-term maintenance of the viral reservoir. However, research of the viral reservoir during acute phase of HIV infection is limited. As a result, cross continental research aimed to expand on this ...
How does BCG affect early innate immune responses?
To determine if BCG affects early kinetics of M.tb infection and lymphocyte recruitment, Delahaye et al., compared immune responses between naive- and BCG-vaccinated mice infected with M.tb. They showed that though BCG vaccination...
Sex associated differences to flu vaccination: role of estradiol?
Researchers have observed sex differences influenza vaccine induced immunity, illustrated by faster seroconversion, higher titres of neutralising antibodies and lower hospitalisation rates in females compared to males. Most of these studies ...
Propagation of α-synuclein from the gut to brain – new causation for Parkinson’s disease?
The cause of Parkinson’s Disease is unknown, with research pointing towards a complex interplay of genetic and environmental factors. New research by Kim et al., however has ...
Have you heard of Mycetoma ?
Evidence from a murine model of mycetoma suggests that IL-17 producing T cells, termed Th17 cells may play a role in mycetoma pathogenesis. IL-17 is a pro-inflammatory cytokine which can play a role in tissue inflammation and can indirectly contribute to neutrophil infiltration.
How does plasmodial hemozoin contribute to cerebral malaria pathogenesis?
Phagocytic ingestion of hemozoin results in production of pro-inflammatory cytokines and reactive oxygen species (ROS), thus suggesting a potential mechanism of hemozoin induced immuno-pathogenesis. Rualf et al., used...
Are neutrophils in the tumor microenvironment friend or foe?
Neutrophils have been implicated in tumor pathology, where studies have reported a positive association between high neutrophil levels and tumor progression. Researchers from Europe (Ponzetta et al.,) aimed to determine...