P.falciparum is able to modulate the RBC’s membrane stiffness. However, can P.falciparum remodel naïve surrounding RBCs in preparation for invasion while growing inside their host RBC?
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Pregnant women show elevated levels of anti-inflammatory glycosylation patterns of IgG antibodies
Damelang et al. investigated the ability of IgG antibodies, specific to DBL2 and DBL3 (two VAR2CSA domains), of pregnant women from a malaria-endemic area to activate human primary NK cells from malaria-naïve donors.
First report on Effectiveness of HPV Vaccination in LMICs – Rwanda and Bhutan
HPV infection is attributable to about 99.7% of cervical cancer cases globally in addition to other anogenital and oropharyngeal cancers. Researchers have recently published data from Rwanda and Bhutan that demonstrate HPV vaccine effectiveness in LMICs.
Does ACE2 expression & cytotoxic lymphocyte levels indicate a risk factor for COVID-19?
Article in the American Society of Microbiology outlined how differences in expression within lung tissue may impact the effect of SARS-CoV-2 infection on the individual.
Immunopathogenesis of Autoimmune Hepatitis
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease that occurs at any age and mainly affects women. Understanding the immunopathogenesis of AIH is crucial for the development of treatment strategies.
B1.351 (501Y.V2) induces cross-reactive Ab responses to other SARS-CoV-2 variants.
Moyo-Gwete et al., 2021 demonstrated that 501Y.V2 elicits robust neutralizing antibody responses against both the original variant and 501Y.V3 (P.1), which indicates high levels of cross-reactivity. Watch video summary for..
IUIS-Immunopaedia-Frontiers Webinar on Immunology taught by P. falciparum
Using a systematic search for antibodies that bind broadly to infected erythrocytes, they discovered a new class of Abs generated by insertions of genomic DNA encoding human inhibitory receptors (LAIR1) into antibody genes.
Is tumour circulating DNA a better tool for cancer diagnostic and prognostic than immunological biomarkers?
Although head and neck squamous cell carcinomas (HNSCCs) is the seventh most frequent type of cancer, they both still have no validated biomarkers and lack specific therapies.
HPV & HIV infection are associated with high levels of activated CD4 T cells in the cervix uteri
To dissect the effect of HIV and HPV on cervical immunity, Mbuya et al. analysed the expression of activation and memory markers on systemic and cervical T cells in relation to HIV or HPV infection.
Predicting tissue graft outcomes using immune markers
An Italian research team has recently shown that immune markers, CXLC10 and IL-6, are able to predict the viability of grafts taken from donor patients who have suffered brain death. Researchers hope that routine measurement of these markers in patients...