In a recent study, researchers aimed to characterise the presence of autoantibodies against autoantigens associated with known autoimmune diseases...
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Immunotherapy – new insights into how CD8+ T cells become unresponsive to treatment
In a recent paper, Horten, et al., have revealed potential causes for T cells exhaustion and how this subset may become non-responsive to immune checkpoint blockade (ICB).
Predicting response to immunotherapy in patients with clear cell renal cell carcinoma (ccRCC)
Recently, researchers have identified patterns within tumours that will help with predicting if patients with kidney cancer will respond to immunotherapy.
Pregnancy and its influence on the immune response to SARS-CoV-2
A recently published focus article has highlighted two interesting studies which investigated the response of pregnant women to natural infections and COVID-19 vaccines. The results are interesting...
Toxoplasma gondii-Induced Neutrophil Extracellular Traps Activate Neutrophils and promote T cell recruitment
Researchers have now determined the activation status of human neutrophils from patients with acute and chronic infections of T. gondii using flow cytometry.
Neutrophils as potential early indicators of tuberculosis severity
Researchers have made use of flow cytometry to monitor frequencies, phenotype and function of stimulated neutrophils from HIV-negative TB patients...
Microbial fitness and IgA – a balancing act for the intestinal flora
Researchers have recently shown in a murine model that IgA antibodies regulate and modulate, at several levels, the activity of non-pathogenic bacteria...
Malaria Vaccine Breakthrough: Shaking or Stirring the Field?
Being the first and the only approved vaccine of a deadly parasitic disease makes RTS, S a potential part of malaria-control tool kit. This vaccine will help in lowering the tide of the disease-malaria...
A novel immunogene CD47-targeting therapy inhibiting tumour growth
Researchers have now developed a novel therapy concept for programming the tumour cells to produce a CD47-blocking and immune-activation fusion protein in the hope that this will halt tumour growth...
A novel inhibitor of dengue virus
In a recent study conducted by researchers at the Rega Institute for Medical Research, KU Leuven, have identified and developed an ultrapotent inhibitor of the dengue virus (DENV), which causes the tropical disease known as dengue.