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Beites, et al., have investigated the function and role of an Mtb enzyme that has never been studied in detail. They reported that the enzyme is essential for Mtb's breakdown of free fatty acids which in turn lead to energy generation and the molecular building blocks for growth and survival.

A recent article published in Kidney International highlights novel findings concerning Tertiary lymphoid tissues (TLTs), which are ectopic lymphoid tissues formed due to chronic inflammatory microenvironment which functions as a local center for priming immune response.

Avolio, et al., reported that the protein CSDE1 coordinates a complex chain of events that enable senescence in skin cells, significantly slowing down their function without causing death.  The result, cells that acting like a wall to protect one against cancer, further suppressing the formation of tumours.

Van Breemen, et al., reported on a pair of cannabinoid acids, cannabigerolic acid (CBGA) and cannabidiolic acid (CBDA), that can bind to the SARS-CoV-2 spike protein, inhibiting/blocking a crucial element of the virus’s ability to infect a host cells.

A recent study using murine models has reported that an antimicrobial found in toothpaste, triclosan (TCS), in addition to other toys and products, can lead to or trigger gut inflammation. Zhang, et al., have characterised the bacteria and specific enzymes that are responsible for triggering TCS’s adverse effects.

In a recent discovery that may aid researchers in identifying new targets for cancer treatment, Belyaeva, et al., 2021 have discovered how immune cells protect themselves when they enter and squeeze between tissue cells.

In a recent observational study, De Marco, et al., investigated mechanisms of how the Omicron variant of SARS-CoV-2 (B.1.1.529) evades cellular immunity. An interesting paper and extremely relevant during these times...

A recent study published in Nature Immunology, highlighted how the loss of TET enzymes can lead to B cell lymphoma. The study by Shukla, et al., may provide us with opportunities for designing novel drug treatment strategies to target cancerous cells.

In a recent preprint, Warwicker investigated the degree to which the D614G mutation in the SARS-CoV-2 receptor-binding domain (RBD) allows access of spike (S) protein trimers to conformations/forms similar to the linoleic acid (LA)-bound locked conformations without LA binding. 

In a recent study, Schumann, et al., made use of selection-linked integration (SLI) in combination with glmS ribozyme-tagging and established a purification protocol for recombinant PfKelch13 to study the relevance of the abundance, conformational stability, and redox state of PfKelch13 for the artemisinin susceptibility in P. falciparum.