In a recent paper, researchers hypothesised the role of IL-25 in directly regulating bronchial epithelial cells (BEC) innate immunity during viral infection and that inhibition of IL-25 would lead to increased IFN expression and reduced viral load...
2022
Using bacteria to fight cancer
In a recent paper, researchers sought to deepen our understanding of the role of macrophages and inflammasome activation in the context of an attenuated Salmonella (LVR01) therapy against melanoma...
Unique genes: the innate immune response and tuberculosis
In a recent paper, Khan, et al., hypothesized that the MΦ phenotype can enhance anti-TB function following cytokine stimulation, and this stimulation can explain the development of LTBI...
SARS-CoV-2 Omicron variant in hamsters is not as deadly as we think
In a recent paper, researchers investigated the respiratory tract and described the pathogenicity of Omicron variant in comparison to other variants of concern...
Nasal spray immunisation: potential use against HIV and SARS-CoV-2 shown in an animal models
In a recent paper by Hartwell, et al., the researchers tested whether albumin-binding amph-vaccines would enable and enhance FcRn-mediated vaccine uptake within the nasal mucosa...
Cancer, collagen the microbiome and immunity – a link!
In a recent study, researchers have described how cancer cells can produce small amounts of collagen that form a unique matrix which effects the tumour microbiome, protecting it from the immune response...
COVID-19 and the brain – new insights
In a recent paper, researchers found that certain antibodies mark cells, mistakenly, lining the brain's blood vessels for attack which leads to an inflammatory responses and tissue damage, following SARS-CoV-2 infection and subsequent COVID-19 disease...
Can reprogramming CD8 T-cells contribute to a cure for a HIV?
In a recent paper, researchers investigated the reprogramming of CD8+ T-cells from non-controllers and tested if it could lead to a boost in their antiviral immune response, as a result of their CD8+ T-cells exhibiting characteristics seen in natural controllers...
An inflammatory pathway linked to autoimmune diseases
In a recent paper, researchers have identified and described a biochemical pathway that is essential for the production, transport, and action of oxidised mtDNA which may trigger inflammation in the body...
Developing new tools to combat COVID-19
Hans-Martin, et al., reported the isolation of monoclonal antibodies from TRIANNI mice, which can be used to provide a pair of non-competing human monoclonal antibodies for clinical development...