In a new study, researchers sought to find out what role CD4 T-cells play when it comes to aiding the tumour-suppressing function of CD8 T-cells, and possibly unpack the exact mechanisms that can account for the immunosurveillance observed from CD4 T-cells...
August 2022
Blocking of an important coronavirus enzyme with natural compounds
In a new study, researchers have screened a large library of natural substances using X-ray and found that they bound to an enzyme which is essential for replication of the coronavirus...
Helminths and Vaccine responses
In a recent systematic review, researchers systematically reviewed existing literature on the effects of helminth infections and their treatment on vaccine responses in humans and animals...
A map of the immune system
In a recent paper, researchers have successfully created the first comprehensive map of the human immune system, illustrating all connections in full and describing the communication between immune cells and how we can use this as a tool to investigate disease and develop new therapeutics...
CD8 T-cell mediated vaccine protection against SARS-CoV-2
In a recent paper, researchers described the effects and role of CD8+ T-cell responses following vaccination with Ad26.COV2.S (Janssen/Johnson & Johnson) in the response against SARS-CoV-2 infection utilising a rhesus macaques model...
The emergence of inflammatory monocytes as the leukemia anteroom.
In a recent paper,researchers have developed a novel mouse model carrying a TET2 missense mutation which develop a broad spectrum of myeloid cancers late in life in order to map the transition from indolent hematopoiesis to pathological states...
New insights into the interferon response to SARS-CoV-2
In a recent paper, researchers have investigated several SARS-CoV-2 variants to describe how the innate immune system responds to infection. They specifically looked at the interferon response to SARS-CoV-2 infection.
Distinct antibody responses as biomarkers to monitor cancer immunotherapies
In a new study, researchers described how pre-existing and treatment-induced antibodies against specific antigen targets could reflect the response elicited by anti-tumour drugs and that this response could be predictive of cancer immunogenicity and therefore...
Promising new insights: the immune response following a stroke
In a recent paper, researchers have found that CD8+ regulatory-like T cells release neuroprotective molecules in the brain following a stroke, which may limit inflammation and subsequent brain damage...
IL-25 blockade as a therapeutic strategy for asthma
In a recent paper, researchers hypothesised the role of IL-25 in directly regulating bronchial epithelial cells (BEC) innate immunity during viral infection and that inhibition of IL-25 would lead to increased IFN expression and reduced viral load...