In a recent paper, Ercanoglu, et al., sought out to provide a detailed analysis of the B cell immunity to SARS-CoV-2 in unexposed individuals, investigating pre-pandemic blood samples from 150 adults........
March 2022
Enhanced production of effective and personalised vaccines for cancer
In a recent paper by Feola, et al., researchers have developed a pipeline for evaluating, prioritising and identifying potential tumour antigens for the production of vaccines against cancers. The pipeline currently being validated...
COVID-19: antigen-specific T cell response and immuno-metabolomic signatures
In a new study by Binayke, et al., the researchers investigated the innate and adaptive immune responses during both the late and early stage of SARS-CoV-2 infection. They also wanted to establish the relationship between early and late stage infection and the immune responses...
Biomarkers to identify Mycobacterium tuberculosis-infection: finding the needle in a haystack
In a recent paper, the authors sought to identify a biomarker profile that can be used to differentiate borderline QFT results, due to TB-infection, from those that are a result of random test variation...
T cells and skin disease
Roediger, et al., suggested that the role of T cells, particularly due to their implication in the TH2 phenotype, in Inflammatory skin disease (ISD) could be a therapeutic avenue which can extend to cutaneous lymphoma disease (CTCL)...
B-cell immunity following SARS-COV-2 mRNA vaccination – 6 months on…
In a recent paper by Markewitz, et al., the researchers aimed to investigate and determine the levels of anti-SARS-CoV-2 antibodies in individuals who have been vaccinated with a mRNA COVID-19 vaccine six months after receiving their second dose...
A potential mRNA vaccine for SARS-CoV-2 Omicron variant
In a recent study, Wu, et al., aimed to develop a messenger ribonucleic acid (mRNA) vaccine using the SARS-CoV-2 Omicron variant sequence as a target. The aim was to develop a vaccine capable of generating nAbs in multiple animal models against the Omicron variant...
More than a gut feeling: The implication of gut microbiota in the pathology of Alzheimer’s Disease
A recent study by Verhaar et al, investigated associations among patients with Alzheimer's' disease pathology and their gut microbiota. This study demonstrates that the gut microbiome composition is linked to biomarkers of AD pathology...
MAIT cells – a new target for future immunotherapies and vaccines
In a recent study, researchers have demonstrated that mucosal-associated invariant T (MAIT) cells, a form of immune cells, play several complex roles during diseased and healthy conditions. These MAIT cells may be used as targets for immunotherapies and vaccines.
Immune memory in the intestine: new insights into “innate memory”
In a recent paper, Serafinain, et al., have made us of an intestinal infection model to discover that group 3 innate lymphoid cells (cells of the innate immune system) may also develop an innate form of immunological memory...