2021

Recently, researchers have identified a novel antibacterial mechanism, potentially paving the way for new therapeutics to combat Staphylococcus aureus infection and other bacterial infection.

Through the investigation of novel biological features explaining COVID-19 severity and prognosis (death and disease progression), researchers have developed a novel predictive tool which they have made publicly available...

8 September 2021 In a recent Pre-print, Keeton et al., examined the effect of prior infection with ancestral (D614G) or Beta variants on Ad26.COV2.S immunogenicity approximately 28 days...

3 September 2021 Preeclampsia (PE) is a devastating disorder which effects more than 3-5% of pregnancies worldwide and remains to be one of the leading causes of global maternal and perinatal mortality and morbidity. Having previously observed aberrant expression of human leukocyte antigen (HLA)-DR molecules in the syncytiotrophoblast of a subset of women with PE...

Through the use of single-cell transcriptome, proteome, and immune cell analysis of the tumour microenvironment (TME), Hicks, et al., were able to show that that combination therapy elicits significant and sustained anti-tumour efficacy and complete responses by shifting the TME to a functionally inflamed landscape.

In a recent preprint, Riou and colleagues aimed to provide an overall measure of immune evasion by assessing neutralizing antibody and T cell responses in 44 South African COVID-19 patients infected either with B.1.351 or infected before its emergence (‘first wave’).

In an interesting study, researchers showed that neutrophils contribute significantly to IgG-mediated phagocytosis of blood-stage P. falciparum merozoites and protection against febrile malaria. These findings further elucidate neutrophil antibody-mediated immune mechanisms...

Researchers from the University of Maryland and the US National Institutes of Health have discovered a novel pathway of host cell manipulation and innate immune evasion by Mtb. They have shown that the Mtb limits activation of a host cell defense complex, the inflammasome.

Researcher aimed to develop a candidate SARS-Cov-2 vaccine that uses the YF17D vaccine as a vector to express a non-cleavable pre-fusion form of the SARS-CoV-2 spike antigen (YF-S0).

We highlight recent research that investigated whether neutrophil conversion to neutrophil antigen presenting cells (nAPCs) requires the engagement of their Fcγ receptor, as well as exploration of the therapeutic potential of nAPCs. Using a murine model, authors demonstrated that uptake of antibody-antigen...