April 2021

Since nothing is known about aged neutrophils in cancer biology and mature neutrophils in the circulation are considered to be heterogenous, Peng et al. examined how metastatic cancers regulate mature neutrophils. To this end, they induced tumor growth in mice by injecting cells from breast cancer ...

P.falciparum is able to modulate the RBC’s membrane stiffness. However, can P.falciparum remodel naïve surrounding RBCs in preparation for invasion while growing inside their host RBC?

Damelang et al. investigated the ability of IgG antibodies, specific to DBL2 and DBL3 (two VAR2CSA domains), of pregnant women from a malaria-endemic area to activate human primary NK cells from malaria-naïve donors.

HPV infection is attributable to about 99.7% of cervical cancer cases globally in addition to other anogenital and oropharyngeal cancers. Researchers have recently published data from Rwanda and Bhutan that demonstrate HPV vaccine effectiveness in LMICs.

Article in the American Society of Microbiology outlined how differences in expression within lung tissue may impact the effect of SARS-CoV-2 infection on the individual.

Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease that occurs at any age and mainly affects women. Understanding the immunopathogenesis of AIH is crucial for the development of treatment strategies.

Moyo-Gwete et al., 2021 demonstrated that 501Y.V2 elicits robust neutralizing antibody responses against both the original variant and 501Y.V3 (P.1), which indicates high levels of cross-reactivity. Watch video summary for..

Using a systematic search for antibodies that bind broadly to infected erythrocytes, they discovered a new class of Abs generated by insertions of genomic DNA encoding human inhibitory receptors (LAIR1) into antibody genes.

Although head and neck squamous cell carcinomas (HNSCCs) is the seventh most frequent type of cancer, they both still have no validated biomarkers and lack specific therapies.