Since SARS-CoV-2 is airborne, we would be better served by a vaccine that would be delivered intranasally in order to promote an IgA response that targets the virus at mucosal sites rather than an intramuscular administration that predominantly induces IgG that have a limited contribution to the mucosal immunity.
November 2020
Testing potential neonatal sepsis drugs using a murine neonatal sepsis.
Using the E.coli neonatal sepsis model researchers demonstrated dissemination of E.coli to other parts of the body including the brain was also associated with detection of detrimental sepsis-associated inflammatory cytokines. They showed that PTX modestly decreased TNF levels, but significantly increased levels IL-10.