A recently published article in Cell showed the presence of SARS-CoV-2−reactive CD4+ T cells in up to 60% of unexposed individuals – suggesting the presence of cross-reactive T cells. The authors used a set of peptide ‘megapools’, derived from predicted peptides restricted by several HLA class I and II, and found that 70-100% of COVID-19 convalescent patients had reactive...
June 2020
Is the rapid generation of neutralizing antibodies to SARS-CoV-2 good news for preventing reinfection?
A recent pre-peer reviewed article in medRxiv reports on the dynamics of neutralizing antibody responses to the receptor-binding domain (RBD) of the spike protein. Investigators examined 44 COVID-19 patients and found that class-switching occurred early during infection and was by RBD-specific IgG1 and IgG3 responses. They also detected both RBD-specific IgM ...