Epidemiological studies have associated measles infection with increased childhood morbidity and mortality up to 5 years post-infection. This association could be due “immunological amnesia” where measles infection has been reported to deplete of memory B and T cells, as well as plasma cells. However, to date, no studies have directly demonstrated measles...
January 2020
SEPSIS is WANTED!
Sepsis is life-threatening organ dysfunction due to a dysregulated host response to infection (Singer et al., 2016). Sepsis is actually recognised as a major global health problem, and the World Health Assembly has urged member states to strengthen efforts to identify, document, prevent, and treat sepsis.
Discovery of novel cancer signalling mechanism
Active mutations in KIT tyrosine kinase are found in several cancers, such as acute myeloid leukemia (AML). However, the different locations in the AML cells where KIT induces cancer-specific signaling remain unclear. Scientists from Japan aimed to...
Macrophages and Cervical Cancer: What’s going on with the microenvironment ?
Sánchez-Reyes et al., evaluated the effect of supernatants from cerival cancer derived-cell lines on the phosphorylation of STAT1, NF-kb-p65 and STAT6 and the impact in the secretion profile of cytokines and growth factors by macrophages...
How DNA outside cells can be targeted to prevent the spread of cancer
Study lead by Prof Ryushin Mizuta, have now discovered exactly how cfDNA is generated. They also talk about the applications of DNase1L3-the enzyme mainly responsible for generating cfDNA-as a novel molecule to prevent the spread of tumors.
Solving the puzzle of IgG4-related disease, the elusive autoimmune
Study lead by Prof. Masato Kubo, “planned to explore how IgG4 Abs contributes to the CTL-mediated pancreas tissue damage in IgG4-RD, and also to evaluate the pathogenic function of human IgG4 Abs using the mouse model that we have established.”
How the rice blast fungus “eats” its own cell wall to launch an attack
In response to environmental changes and nutrient starvation, cells are known to undergo extreme alterations. This includes switching from one type to another (“differentiation”) and changes in metabolic pathways (“metabolic switching”).
Can intravenous-BCG prevent M.tb infection ?
In this article, we highlight a recently published article by Darrah et al., which aimed to determine how dose and route of BCG vaccination influence the generation of systemic and tissue-resident immunity, as well as “protect” against TB. In their study, they vaccinated non-human primates...