anduyt et al., aimed to determine the role of ICOS signalling of Tregs and expression of IL-10 in the colons of mice. As expected ICOS knock out (KO) mice compared to wild type...
2019
How does IL-27 attenuate autoimmune neuroinflammation?
Researchers are currently exploring the potential use of IL-27 as an immunotherapeutic agent. An example of this, is the experimental administration...
CNS-neuroinflammation: not all myeloid cells are responsible
The central nervous system (CNS) is largely considered as an immune privileged site. Recently, this school of thought has been shown to be nuanced...
Immunosenescence: how does it affect vaccine Ab responses ?
Researchers (Henry et al.,) aimed to determine how “ageing” affects influenza vaccine responses. They focused on flu-vaccine responses, as the highest adult flu...
Recurrent Strep throat: when TFH cells “turn on” you
Recurrent episodes of strep throat are particularly common in children, where some develop recurrent tonsillitis (RT). Why some children develop GAS RT and what immunological features...
TB episode following PD-1 blockade
Successful use of PD-1 blockade for cancer immunotherapy, has brought up the question as to whether this same therapy could be successful against infectious diseases such as tuberculosis (TB) and HIV.
Can a vaccine prevent ZIKV associated fetal abnormalities ?
Researchers from Germany aimed to determine whether measles-virus expressing Zika envelope protein E (MV-Zika-sE) sufficiently prevent...
Does mucosal BCG vaccination induce “protective” immunity ?
It is hypothesised that lung mucosal (muc-) BCG vaccination may overcome this pitfall by inducing robust mucosal immunity. Researchers from Netherlands aimed
Are CD8+ and DN MAIT cells distinct populations ?
Study by Dias et al., aimed to determine the difference in transcriptional, activation and functional capacity of CD8+ and DN MAIT cells. They defined MAIT cells...
What can ZIKV-CD8 T cells do ?
Vaccines rely on the induction of adaptive T and B cells responses to confer long term immunity. A potential challenge to inducing protective ZIKV immunity by vaccination, is pre-existing dengue virus (DENV) immunity. Both ...