Raeven et al., conducted an in-depth profiling of Ab repertoire following a pertussis episode in adolescents and young adults with a specific focus on determining the effect of vaccine priming in infancy on subsequent...
2019
Is Yellow fever vaccination safe for HIV+ individuals?
Previous studies have demonstrated variable safety outcomes of yellow fever vaccinated HIV+ individuals. Thus, Colin de Verdiere et al., conducted a safety trial to determine the safety and immunogenicity of profile of YFV...
The emerging role of IL-26 in fighting against intracellular microbes
Dang et al., utilised the human leprosy model to showcase the ability of IL-26 to provide protection against intracellular bacteria. This research opens up the possibility for Th17 cells to also participate in immune...
T cell activation as a potential surrogate marker for TB treatment efficacy.
Ahmed et al., assessed changes in phenotypic markers on MTB-specific CD4+ T cells in peripheral blood mononuclear cells (PBMC) of subjects with active TB from the start to the end of treatment and compared...
Does HIV-env vaccination strategy affect the recognition pattern of IgG responses?
Understanding the factors that influence the vaccine-induced IgG recognition of certain HIV Env regions might aid in an improved and targeted HIV vaccine design.To this end, Nadai et al., closely mapped the IgG response...
Does dysbiosis of the GIT microbiome enhance the neutrophils survival and chronic inflammation in HIV+ individuals?
Microbial dysbiosis in the gut of HIV infected patients, could trigger TLR signalling in neutrophils, increase neutrophil survival and contribute to inflammation and mucosal damage.
Dual BCR and TCR co-expressing lymphocyte could play a role in T1D pathogenesis.
Ahmed et al., discovered this novel lymphocyte population in individuals with type 1 diabetes (T1D), and called it “dual expresser” (DE) cells because they expresses B and T cell specific genes.
M.tb resistors: M.tb uninfected or atypical IFN-𝛾-independent M.tb immune responses ?
Lu et al., demonstrate that resistors possess a distinct adaptive immune phenotype illustrated by detection of mature Ab responses and CD40L expressing (IFN-𝛾 -ve) T cells reactive to...
Course Highlight: 5th Vaccinology in Course
Very few medical interventions compete with vaccines for their cumulative impact on global health. For this reason, the Jenner institute, University of Oxford and Pirbright started vaccinology courses in Africa, where global burden of vaccine preventable...
Immunoinformatics Mexico 2019: Immunologic plasticity, defense lines.
"To maintain our homeostasis we need to constantly change and adapt to the environment," said Mariana Martínez Sánchez, during her presentation titled “Plasticity in the Immune System: From Model to Mechanisms” at Immunoinformatics 2019.