Early detection of breast cancer offers curable options, however, once metastasized the cancer cannot be cured. With higher rates of breast cancer correlated with western diet consumption...
2019
The Vaccinology course, if you are in the vaccine-world, you shouldn´t miss it!
Since 2008 the Institut Pasteur in Paris, France has facilitated the Vaccinology Course, a course that covers all aspects of vaccines and vaccination, and allows participants from all over the world to attend lectures by immunologist who conduct cutting-edge research.
Investigating the immunological composition of the Kidney
Researchers recently published an article in Science (Stewart et al.,) describing the immune composition of anatomical structures of the kidney, and how they differ between early life (fetus) and adulthood. Stewart et al., obtained kidney...
CD27 expression identifies Th17 cells with high stemness properties
Karmaus et al., showed that during chronic autoimmunity Th17 cells are heterogenous, where Th17 cells with enriched stemness properties are CD27+TCF1hi, while IFN-γ expressing Th17 cells with high metabolic activity are CD27-Tbethi.
New fungus-derived antibiotic: relief in sight for immunocompromised people
Scientists derive a new compound from eushearilide, which can potentially take on lethal fungal and bacterial infections.Infections that are treatable in healthy people can often be fatal in immunocompromised individuals ...
HIV RV144 vaccine induces better responses in SA compared to Thailand
Amazing results from the RV144 trials indicated the potential of this vaccine, thus Gray et al., 2019 designed a study (HVTN097) to determine safety and immunogenicity of the RV144 vaccine regimen in South Africans.Why test an HIV-subtype B/E vaccine...
Rethinking HIV remission strategies: end of the road for anti-α4β7 ?
Byrareddy et al., 2016 (HIV R4P Highlights: α4β7 antibody and ART: a novel HIV therapy) demonstrated the ability of anti-α4β7 in preventing viral rebound in the absence of ART. This promising result provided sufficient motivation to conduct a phase 1 clinical trial...
GLA-SE promotes superior Tfh expansion than Alum
Since Tfh cells play a critical role in the generation of long-live Ab responses, targeting them using adjuvants is a potential way of improving vaccine strategies. Tfh cells are relatively understudied in human vaccine studies because...
Class-switch recombination of antibodies occurs prior to germinal center formation.
It is believed that upon immunization, two important processes occur that alter the function and reactivity of antibodies (immunoglobulins, Ig) resulting in long-lasting immune protection. One process is a change in antigen reactivity...
Can anti-α4β7 really “cure” SIV infection in ART interrupted NHPs ?
Byrareddy et al. showed that targeting α4β7 using antibodies can prevent HIV viral rebound in the absence of ART in NHPs. Researchers have attempted to replicate Byrareddy et al., findings and 3 of these studies recently published...