Scientists derive a new compound from eushearilide, which can potentially take on lethal fungal and bacterial infections.Infections that are treatable in healthy people can often be fatal in immunocompromised individuals ...
September 2019
HIV RV144 vaccine induces better responses in SA compared to Thailand
Amazing results from the RV144 trials indicated the potential of this vaccine, thus Gray et al., 2019 designed a study (HVTN097) to determine safety and immunogenicity of the RV144 vaccine regimen in South Africans.Why test an HIV-subtype B/E vaccine...
Rethinking HIV remission strategies: end of the road for anti-α4β7 ?
Byrareddy et al., 2016 (HIV R4P Highlights: α4β7 antibody and ART: a novel HIV therapy) demonstrated the ability of anti-α4β7 in preventing viral rebound in the absence of ART. This promising result provided sufficient motivation to conduct a phase 1 clinical trial...
GLA-SE promotes superior Tfh expansion than Alum
Since Tfh cells play a critical role in the generation of long-live Ab responses, targeting them using adjuvants is a potential way of improving vaccine strategies. Tfh cells are relatively understudied in human vaccine studies because...
Class-switch recombination of antibodies occurs prior to germinal center formation.
It is believed that upon immunization, two important processes occur that alter the function and reactivity of antibodies (immunoglobulins, Ig) resulting in long-lasting immune protection. One process is a change in antigen reactivity...
Can anti-α4β7 really “cure” SIV infection in ART interrupted NHPs ?
Byrareddy et al. showed that targeting α4β7 using antibodies can prevent HIV viral rebound in the absence of ART in NHPs. Researchers have attempted to replicate Byrareddy et al., findings and 3 of these studies recently published...
New insights into the role of HPV oncoproteins and immune response in cervical cancer
Cervical cancer, one of the top 5 common cancers in women globally, is often associated with high-risk human papillomavirus (HPV) infections such as oncogenic HPV16 and HPV18.
Did you know neutrophils can help to form gallstones?
Despite the high morbidity, the mechanism of gallstones development, specifically factors that contribute to cholesterol and calcium aggregation is not well understand. Recent research published in Immunity by Muñoz et., al...