Developing a murine model that recapitulates human infection is challenging. Sateriale et al., aimed to develop a murine model of Cryptosporidiosis that is similar to human infection and can be used to test potential vaccine strategies.
June 2019
Does whole cell pertussis vaccination skew infection induced Ab profiles?
Raeven et al., conducted an in-depth profiling of Ab repertoire following a pertussis episode in adolescents and young adults with a specific focus on determining the effect of vaccine priming in infancy on subsequent...
Is Yellow fever vaccination safe for HIV+ individuals?
Previous studies have demonstrated variable safety outcomes of yellow fever vaccinated HIV+ individuals. Thus, Colin de Verdiere et al., conducted a safety trial to determine the safety and immunogenicity of profile of YFV...
The emerging role of IL-26 in fighting against intracellular microbes
Dang et al., utilised the human leprosy model to showcase the ability of IL-26 to provide protection against intracellular bacteria. This research opens up the possibility for Th17 cells to also participate in immune...
T cell activation as a potential surrogate marker for TB treatment efficacy.
Ahmed et al., assessed changes in phenotypic markers on MTB-specific CD4+ T cells in peripheral blood mononuclear cells (PBMC) of subjects with active TB from the start to the end of treatment and compared...
Does HIV-env vaccination strategy affect the recognition pattern of IgG responses?
Understanding the factors that influence the vaccine-induced IgG recognition of certain HIV Env regions might aid in an improved and targeted HIV vaccine design.To this end, Nadai et al., closely mapped the IgG response...
Does dysbiosis of the GIT microbiome enhance the neutrophils survival and chronic inflammation in HIV+ individuals?
Microbial dysbiosis in the gut of HIV infected patients, could trigger TLR signalling in neutrophils, increase neutrophil survival and contribute to inflammation and mucosal damage.
Dual BCR and TCR co-expressing lymphocyte could play a role in T1D pathogenesis.
Ahmed et al., discovered this novel lymphocyte population in individuals with type 1 diabetes (T1D), and called it “dual expresser” (DE) cells because they expresses B and T cell specific genes.