Castellano et al., demonstrated the importance of glutamine and glutamate to the survival of these latently-infected macrophages by showing that there was a decrease in the number of cells that survived...
March 2019
PD-1/PDL1 pathway in the maintenance of maternal-foetal immunotolerance
Meggyes et.al in this paper has highlighted the role of PD-1/PDL1 pathway during pregnancy. They recruited healthy women who underwent pregnancy termination for non-medical reasons in the first trimester...
How does the complement cascade result in pore formation in Lampreys
Lampreys possess an alternate immune system that employs VLR recombination instead of VDJ recombination as seen in jawed vertebrates. Previous studies showed that lamprey pore formation...
HIV complications: inflamma-aging or increased activation ?
It has been suggested that “inflamm-aging” is due to immune exhaustion which is associated with reduced effector functions and increased expression of inhibitory receptors (IRs). Thus, Belkina et al.,
Does BCG improve de novo malaria immunity ?
There is limited research on the impact of BCG on malaria. Murine models have shown that BCG reduces parasitaemia in mice compared to controls. Researchers aimed to provide...
Hematopoietic stem cell transplantation cures HIV
Study by Gupta et al., reports for the second time, that HIV can be cured by using allogeneic stem cell transplantation from a donor that has a homozygous genetic deletion...
Do neutrophils play a role in age-associated increase in flu mortality?
Influenza virus infection causes more mortality in elderly compared to younger people, and one of the main reasons could be aging of the immune system. Aging impairs both innate ...
Do NK cells play a role in vaccine induced humoral immunity ?
Natural killers cells (NKs) are one of the first responders and mediators of inflammation. However, their exact role in vaccine induced immunity is not adequately defined.
ICOS: is it essential for Treg-IL10 expression in the colon?
anduyt et al., aimed to determine the role of ICOS signalling of Tregs and expression of IL-10 in the colons of mice. As expected ICOS knock out (KO) mice compared to wild type...