Since the discovery of the Coley toxin in the 19th century, bacterial based immunotherapies have been evaluated for the treatment of cancer. In this regard, Salmonella...
December 2018
Plasmablast formation: which T helper phenotype is important?
Researchers from the University of Minnesota used an in vivo murine model of vaccination to assess the role of Tfh, Th1 or Th17 cells in plasmablast...
Organ specific replenishment of tissue resident macrophages
Lai et al., utilized a murine model of blood stage malaria, where mice were infected with non-lethal Plasmodium yoelii which self resolves. Blood stage malaria causes a systemic ...
IDA Highlights: Innate signatures of HIV vaccines
The innate signatures for 4 HIV recombinant vaccine vectors (MRKAd5/HIV, ALVAC ,MVA and Vesicular Stomatitis Virus (VSV) and their respective adjuvants have been evaluated or are under...
IDA Highlights: TB vaccines
The future vaccination against TB will likely be based on heterologous prime-boost strategies. These strategies consist of subsequent vaccinations with new vaccine candidates following primary BCG vaccination ...
IDA Highlights: HIV Immunity
The lymph nodes has shown to be one compartment with highest rates of HIV replication and yet has a restrictive trafficking of cytotoxic CD8 T-cells into the tissues (Michael Betts). However ...