30th October 2018 Ferrando-Martinez et al., showed that SIV-specific follicular (f)CD8 T cells are observed in both intact and disorganised lymph node follicles, and accumulate during chronic infection.
October 2018
Are alveolar macrophages M1 or M2 polarised?
26th October 2018 Collaboration between researchers from the United Kingdom and Malawi, aimed to investigate the polarisation of AMs detected in bronchoalveolar lavage (BAL). Studies have shown that live...
Identifying disease-associated populations in the age of big data
23rd October 2018 Researchers aimed to identify RA disease-associated cell subsets using high dimensional single cell analysis. Previous studies have observed increased proportions of CD28-CD4+ T cells in...
IgD: the lesser known antibody
17th October 2018 Unlike immunoglobulin (Ig) M, IgG, IgA and IgE, the role of IgD in antibody mediated immunity is unknown. IgD is co-expressed with IgM on mature B cells, and is best known for its function as a B cell antigen receptor. Upon antigen exposure ...
MAIT cell dysfunction during primary sclerosing cholangitis
15th October 2018 Seth and colleagues aimed to characterise the phenotype and function of MAIT cells in samples from patients with PSC. Researchers defined MAIT cells as CD161+Vα7.2 T cells that were either ...
How does bacterial-viral co-infection impact anti-viral immunity?
10th October 2018 To shed light on how bacterial infection affects LCMV induced immunity, researchers infected mice with E.coli a day post LCMV infection. Straub et al., showed that E.coli ...
Antibodies and TLR7 agonist delays HIV viral rebound
5th October 2018 Borducchi et al., aimed to evaluate the capacity of the potent neutralising antibody (NAb) PGT121 and the TLR7 agonist vesatolimod (GS-9620) to target the viral reservoir in ART- suppressed ...
Lower efficacy of tumour immunotherapy in obesity is due to elevated Leptin
3rd October 2018 Murphy et al., investigated the impact of obesity on immunotherapeutic strategies. The two therapies tested were the (i) experimental intratumoural delivery of recombinant adenovirus ...