31st August 2018 A study conducted by Scott et al., utilized a novel method to develop e-cigarette vapour condensate that is physiologically similar to the vapour e-cigarette users are exposed to. Scott et al., demonstrated that e-cigarette vapour condensate ...
August 2018
α4β7-MAdCAM interaction promotes HIV replication.
29th August 2018 Several studies with non-human primates (NHPs) have shown that in -vivo administration of an antibody against the integrin can induce persistent Simian immunodeficiency virus (SIV) control, delay disease progression, and reduce viral titres ...
Comparing H56 responses in NHP and humans using mathematical modelling.
26th August 2018 Researchers whom tested H56 candidate vaccine in NHPs and humans used mathematical modeling to compare vaccine induced immunity between these two species. H56 is a TB candidate vaccine that contains Mycobacterium tuberculosis (M.tb) antigens ...
Fatal SFTSV is associated with defective B cell responses
22nd August 2018 Severe Fever with Thrombocytopenia Syndrome (SFTS) is an emerging infectious disease with a 10-30% fatality rate. SFTS is caused by Phlebovirus (also referred to as SFTSV) and is predominantly transmitted by ticks ...
Potential treatment for metastatic colorectal cancers: T cell engaging bispecific antibodies
17th August 2018 While improvements in screening procedures and treatments have improved colorectal cancer (CRC) patient outcomes, CRCs still account for 9-10% of all cancers worldwide. While localized cases of CRC are more easily treated, patients with ...
How do γδ T cells control humoral immunity ?
14th August 2018 γδ T cells have also been shown to participate in induction of humoral immune responses by helping B cells. Whether γδ T cells directly interact with B cells or indirectly affect humoral immunity is not known. Additional studies have shown than γδ T cells promote B cell hypermutation by expressing ...
Can antibiotic treatment improve Rotavirus immunogenecity?
10th August 2018 Harris et al., designed a proof-of concept clinical trial that aimed to determine if mimicking some of the bacterial phenotypes observed in the observational studies is associated with improved RVV-induced immune responses.
Clade C RV144-like vaccine is immunogenic.
7th August 2018 Bekker and colleagues conducted the HVTN100 phase 1/2a clinical trial which aimed at determining the safety and immunogenicity of the Subtype C ALVAC-HIV and bivalent subtype C gp120/MF59 HIV-1 vaccine in low-risk, HIV-uninfected. adults in South Africa ...
Can B cell responses predict resolution of Lyme Disease?
3rd August 2018 Lyme disease is an infectious disease caused by Borrelia burgdorferi (Bb). Infection ...