30th May 2018 Srivastava et al., aimed to determine if CXCL17 is essential for recruiting antiviral CXCR8+ CD8+ T cells, and whether these cells contribute to protective immunity against genital herpes.
May 2018
Vaccine induced monocyte activation contributes to decreased risk of SIV acquisition
28th May 2018 Vaccari et al, hypothesized that changing vaccine type and/or vector may improve efficacy of the ALVAC-SIV+ gp120 alum vaccine. They tested a DNA-SIV...
Tuft cell tropism may aid norovirus pathogenesis
24th May 2018 Norovirus is a highly infectious virus responsible for approximately 700 million cases and 200,000 deaths due to acute viral gastroenteritis annually. Norovirus tropism in humans ...
First Animal Model of Rasmussen’s encephalitis
22nd May 2018 Rasmussen’s encephalitis (RE), first described in the late 1950s, is a rare inflammatory neurological disease characterised by frequent seizures. The only successful treatment available for Rasmussen's...
Engineering IL-2 cytokine-receptor complexes to improve cancer immunotherapy
18th May 2018 Recombinant human interleukin-2 (rhIL-2) is a US Food and Drug Administration approved adjunct therapeutic for treatment of selective types of cancer.
Reduced Flu severity due to high fibre diet
17th May 2018 Dietary fibre, particularly products of bacterial fermentation of dietary fibre such as short chain fatty acids (SCFAs) acetate, butyrate and propionate have been shown to have anti-inflammatory properties.
CD4 T cell positioning in TB granulomas matters
15th May 2018 Murine models of Mycobacterium tuberculosis (M.tb) have been instrumental in demonstrating the importance of CD4 T cells in the control of M.tb infection.
Have you heard of trained immunity?
11th May 2018 According to classical immunology, only the adaptive arm of immunity i.e. T and B cells have the ability to confer immunological memory. However, understanding of immunology memory is being redefined to included de facto innate ...
Human mAbs protects against Zika Neuropathology in Mice
10th May 2018 The emergent strain of Zika virus (ZIKV) that caused the 2015-16 outbreak in the Americas, is more virulent than the ZIKV first identified in Uganda. One of the most notable clinical anomalies observed in the most recent...
Commensal bacteria leverage IgA during colonisation
7th May 2018 Immunoglobulin A (IgA) is the main antibody found in the gut. Studies about effects of IgA are largely in the context of infection or inflammatory disorders. These studies suggest that IgA may play a crucial ...