27th April 2018 Recent studies suggest the addition of “new” memory phenotype termed peripheral memory T cells (TPM) to the repertoire of memory T cells. TPMs express intermediate levels of CX3CR1 ...
April 2018
Metabolic reprogramming: Novel strategy to improve cancer immunotherapy
25th April 2018 Immunotherapy has emerged as a promising new cancer treatment modality over the last decade. The components of immune-system are the integral part of tumor microenvironment ..
Do monocytes contribute to heamolytic ureamic syndrome?
20th April 2018 Shiga-toxin (Stx) producing enterohaemorrhagic E.coli (STECs) have been implicated in outbreaks of hemolytic uremic syndrome (HUS). HUS is life threatening disease characterized ...
How do mesenchymal stem cells alleviate severe asthma symptoms?
19th April 2018 Asthma is one of the most common respiratory diseases. In spite of improvements in treating asthma, treatment of severe asthma remain a challenge. One of the many avenues being explored ...
Improved tetramer staining protocol detects functional T cells with low affinity TCRs
16th April 2018 Tetramers have become a useful tool in understanding T cell immunology. Tetramers enable detection of T cells directly ex-vivo without the need of in vitro T cell stimulation ...
Harmless γδ T cells associated with Corynebacterium sp. can be harmful during immune dysregulation
13th April 2018 The skin, one of the first lines of immunological defence, is colonised by diverse microbes which play a crucial role ...
Cancer Immunotherapy is associated with changes in innate immunity
11th April 2018 In the 19th century, Doctor William Coley noticed that sarcoma patients went into remission after contracting streptococcus infections. He injected them with
Paratuberculosis in Cattle: Differences in WC1+ γδ T cells responses to stimulation with PPD-J
9th April 2018 Paratuberculosis or Johne’s disease (JD) is a debilitating chronic granulomatous enteritis affecting ruminants ...
Serum IgA induced by commensal microbes protects against sepsis
6th April 2018 Classical understanding of antibody functions state that IgG and IgA antibodies confer protective systemic and mucosal immunity, respectively.
Improved T cell detection by Peptide-MHC dodecamers compared to tetramers
5th April 2018 T cells via the T cell receptor (TCR) recognise peptides (antigens) presented by major histocompability complex ...