TLR-agonist and Salmonella are potential antimelonoma immunotherapy

Since the discovery of the Coley toxin in the 19th century, bacterial based immunotherapies have been evaluated for the treatment of cancer. In this regard, Salmonella...
December 21, 2018
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Plasmablast formation: which T helper phenotype is important?

Researchers from the University of Minnesota used an in vivo murine model of vaccination to assess the role of Tfh, Th1 or Th17 cells in plasmablast...
December 19, 2018
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Organ specific replenishment of tissue resident macrophages

Lai et al., utilized a murine model of blood stage malaria, where mice were infected with non-lethal Plasmodium yoelii which self resolves. Blood stage malaria causes a systemic ...
December 14, 2018
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IDA Highlights: Innate signatures of HIV vaccines

The innate signatures for 4 HIV recombinant vaccine vectors (MRKAd5/HIV, ALVAC ,MVA and Vesicular Stomatitis Virus (VSV) and their respective adjuvants have been evaluated or are under...
December 11, 2018
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IDA Highlights: TB vaccines

The future vaccination against TB will likely be based on heterologous prime-boost strategies. These strategies consist of subsequent vaccinations with new vaccine candidates following primary BCG vaccination ...
December 7, 2018
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IDA Highlights: HIV Immunity

The lymph nodes has shown to be one compartment with highest rates of HIV replication and yet has a restrictive trafficking of cytotoxic CD8 T-cells into the tissues (Michael Betts). However ...
December 4, 2018
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What’s behind Eosinophilic Esophagitis?

30th November 2018 Eosinophilic esophagitis (EoE) is a rare, chronic, food-driven inflammatory disease of the esophagus. Clinical presentation varies through different ages and may include feeding...
November 30, 2018
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IDA Highlights: Malaria

28th November 2018 Antibodies induced by natural infection confer protective immunity in individuals from Malaria endemic regions. Efforts to induce potent vaccine...
November 28, 2018
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IDA Highlight: TB is a complex disease

22nd November 2018 90% of people exposed to  Mycobacterium tuberculosis (M.tb) clear infection or contain the infection (termed as latency), however there is a percentage that progress to active disease.
November 22, 2018
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IDA Highlights: Immune responses at mucosal sites

20th November 2018 The mucosal sites are usually the first entry points of HIV, hence this site is one of the key target areas for anti-HIV immune interventions. To emphasize this point Thomas J Hope ...
November 20, 2018
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