13th October, 2017Due to the widespread use of the smallpox vaccine, the disease was eradicated in 1980. The assumption was that the smallpox vaccine was derived from cowpox virus but since the 1930s it was known that the virus used in the vaccine was...
2017
Short chain fatty acids improve inflammation of the eye
11th October, 2017Immune-mediated inflammation of the uvea is one of the major causes of uveitis. Recent studies have linked intestinal microbiomes and their metabolites to...
Probiotics induce double-positive intraepithelial lymphocytes
9th October, 2017Oral tolerance is important in ensuring that the body does not mount an immune response against everyday foods we ingest. CD4+CD8αα+ double-positive intraepithelial lymphocytes (DP IELs)...
Environmental factors associated with asthma development
6th October, 2017Environmental factors are known to play a role in the onset and pathogenesis of asthma. This study examined the role of pre-natal and early-life environmental...
CXCL13 predicts development of HIV-specific antibodies
4th October, 2017The development of neutralizing antibodies with breadth and potency against HIV in natural infection is of interest because these neutralizing antibodies may confer protection...
HPV-positive cancer cells are dormant in low oxygen conditions
2nd October, 2017Human papillomaviruses (HPVs) are a major health concern as some types have been to shown to cause cervical cancer. Researchers from the German Cancer Research...
IL-4–producing B cells shift T cells to Th2 responses
29th September, 2017T helper (Th) 2 cells have been shown to be important in protection against Schistosoma mansoni while increasing susceptibility to Leishmania major. Researchers...
Type I interferons are important in anti-helminth Th2 immunity
27th September, 2017Type I interferons (IFN) have been traditionally associated with innate immune defences against viruses and bacteria which ultimately result in Th1/17-type...
Trispecific antibody for HIV therapy
22nd September, 2017One avenue that is being explored in a HIV vaccine is eliciting neutralising antibody responses. However, the diversity of the virus has made this challenging. Researchers from the National Institute of Allergy and Infectious Diseases...
Antibodies protect against cytomegalovirus infection
20th September, 2017Human cytomegalovirus (HCMV) is a cause of major concern as it causes severe disease in immunocompromised individuals. Therefore, a vaccine to prevent the virus...