With the recent Ebola cases identified in the Democratic Republic of Congo, the need for a protective vaccine to prevent and control future outbreaks is once again highlighted. Researchers from...
2017
Engineered CD8 T cells flush out HIV reservoirs
When CD4 T cells are infected with HIV, CD8 cytotoxic T cells usually move in to kill the infected cells. However, some CD4...
Targeting an integrin as a potential HIV therapeutic
α4β7 is a gut-homing integrin which is another receptor used by HIV to enter cells. For this reason, it plays a critical role in the pathogenesis of the virus.
Marginal zone B cells in cholesterol control
B cells play an important role in the immune response towards lipoproteins involved in atherosclerosis. Scientists have now discovered a previously unknown role for splenic marginal zone B...
HIV immunogen based on precursor antibodies
More than 30 years after the discovery that HIV is the cause of AIDS, there is still no vaccine for this virus. One of the challenges...
MHC Ib molecule protects against TB infection
Tuberculosis is one of the most dangerous infectious diseases with high morbidity and mortality especially in southern Africa. In this region, TB-HIV...
Broad antibodies from HIV-infected individuals
Although there are numerous antibodies that target HIV, there is no antibody that has been discovered that is able to...
Zika virus persists in cerebrospinal fluid and lymph nodes
Previous studies have shown that Zika virus (ZIKV) persists in certain parts of the body even after the symptoms clear.
How Tregs control liver damage
Regulatory T cells (Tregs) are known to reduce the immune response towards infection in the bid to dampen immunopathology. Researchers have now found a mechanism
GM-CSF and neuroinflammation
28th April, 2017 Certain autoimmune conditions such as multiple sclerosis (MS), hystiocytosis and rheumatoid arthritis, have been associated with dysregulated cytokine...