A recent review evaluated current findings on multigenerational studies of allergy and asthma, where atypical immunological traits may be passed down generations through epigenetics. Multigenerational cohorts where subjects are observed starting from pregnancy...
May 2017
Microbiota in T cell survival
Commensal microbiota found in humans has been found to impact various autoimmune diseases by a link to T cell development. The mechanisms behind this were not well understood. Researchers at the University of Utah School of Medicine, have now...
Early Introduction of Peanuts Prevents Allergies
While many people believe that peanut allergies are confined to Western countries, this growing problem has actually spread to Africa and Asia. The prevalence of peanut allergies in North America...
MyD88-mediated cells against C. rodentium identified
Citrobacter rodentium-induced inflammation is a commonly used animal model for enterohemorragic Escherichia coli (EHEC) infection. It is known that C. rodentium infection is an...
Cross-reactive antibodies for Ebola vaccine
With the recent Ebola cases identified in the Democratic Republic of Congo, the need for a protective vaccine to prevent and control future outbreaks is once again highlighted. Researchers from...
Engineered CD8 T cells flush out HIV reservoirs
When CD4 T cells are infected with HIV, CD8 cytotoxic T cells usually move in to kill the infected cells. However, some CD4...
Targeting an integrin as a potential HIV therapeutic
α4β7 is a gut-homing integrin which is another receptor used by HIV to enter cells. For this reason, it plays a critical role in the pathogenesis of the virus.
Marginal zone B cells in cholesterol control
B cells play an important role in the immune response towards lipoproteins involved in atherosclerosis. Scientists have now discovered a previously unknown role for splenic marginal zone B...
HIV immunogen based on precursor antibodies
More than 30 years after the discovery that HIV is the cause of AIDS, there is still no vaccine for this virus. One of the challenges...
MHC Ib molecule protects against TB infection
Tuberculosis is one of the most dangerous infectious diseases with high morbidity and mortality especially in southern Africa. In this region, TB-HIV...