Protein kinase D2 (PKD2) is activated in T cells when a peptide antigen binds to and stimulates...
2014
Characteristics of memory B Cells following HPV vaccination Immunity
As there are certain pathogens, such as HIV, whose risk to safety prevents the development of live or attenuated vaccines, the need for the development of subunit vaccines becomes more critical. The subunit vaccines for human papillomavirus (HPV) provide near complete protection against HPV …
Antibiotic treatment failure in four common infections- A primary care 1991-2012: longitudinal analysis
An article in this week’s British Journal of Medicine discussed a longitudinal study conducted over 20 years, that looked at antibiotic treatment failure in a primary care setting. Bacterial resistance to antibiotics is a major public health problem. To better understand this in a …
Neutrophil crawling in capillaries- a novel response to MRSA
Methicillin-resistant Staphylococcus aureus (MRSA), is a highly virulent pathogen...
Immune-suppressant vaccine c blocks SIV infection in macaques
A novel vaccine that can be administered orally has been shown...
Short-term changes in HIV viral load and CD4+ cell count
HIV infection in antiretroviral therapy (ART)-naive individuals is typically characterized by a rise...
Group B Strep selected and fixed through use of tetracycline
Streptococcus agalactiae (Group B Streptococcus, GBS) is a commensal of the digestive and genitourinary tracts of humans that emerged as the leading cause of bacterial neonatal infections in Europe and North America during the 1960s. Since this time GBS have lost genetic diversity, and …
Streptococcus pneumoniae forms microlesions in myocardium, disrupting cardiac function
Invasive pneumococcal disease (IPD) seen in the elderly is frequently...
CD45 ligation expands Tregs by promoting interactions with dendritic cells
Regulatory T cells (Tregs), which express CD4 and FOXP3, are critical for modulating the immune response and promoting immune tolerance. It is therefore of great therapeutic importance to find ways to expand Tregs in vivo. This study shows that targeting the CD45 tyrosine phosphatase …
Club cells – identified in Influenza pathogenesis
The immune system’s response to most viral infections, including influenza, is to kill and remove the pathogen. Eliminating infected cells rids the body of the infection. This murine study reports that a special type of epithelial cell in the lungs of mice—called club cells—survive …