Streptococcus agalactiae (Group B Streptococcus, GBS) is a commensal of the digestive and genitourinary tracts of humans that emerged as the leading cause of bacterial neonatal infections in Europe and North America during the 1960s. Since this time GBS have lost genetic diversity, and …
September 2014
Streptococcus pneumoniae forms microlesions in myocardium, disrupting cardiac function
Invasive pneumococcal disease (IPD) seen in the elderly is frequently...
CD45 ligation expands Tregs by promoting interactions with dendritic cells
Regulatory T cells (Tregs), which express CD4 and FOXP3, are critical for modulating the immune response and promoting immune tolerance. It is therefore of great therapeutic importance to find ways to expand Tregs in vivo. This study shows that targeting the CD45 tyrosine phosphatase …
Club cells – identified in Influenza pathogenesis
The immune system’s response to most viral infections, including influenza, is to kill and remove the pathogen. Eliminating infected cells rids the body of the infection. This murine study reports that a special type of epithelial cell in the lungs of mice—called club cells—survive …