Core Immunology – DEV Immunopaedia

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In this Course, you will learn about the basics of immunology.

This is Core knowledge which will help you understand other more complex areas in immunology

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A Snapshot of the Immune System 7 Lessons | 1 Quiz

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Introduction – Snapshot

Generalities of innate immunity

Watch – Complement

Components of the innate immune system

Some Lymphocytes Behave Like Innate Immune Cells

Generalities of Adaptive Immunity

Elements of Adaptive Immunity

A Snapshot of the Immune System Test

Ontogeny of the Immune System 7 Lessons | 1 Quiz

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Introduction – Ontogeny

Hematopoiesis Occurs in Human Bone Marrow

Production of Specific T and B Lymphocytes Occurs in Antigen-Independent and Antigen-Dependent Phases

T Cell Development Originates in the Thymus – Functional Effector Cells and Memory Cells Are Produced in Peripheral Lymphoid Tissues

B Cell Development Begins in the Bone Marrow – Functional Effector Cells and Memory Cells Are Produced in Peripheral Lymphoid Tissues

Natural Killer Cells Also Develop in the Bone Marrow

The Mature Immune System

Ontogeny of the Immune System Test

The Innate Immune System 10 Lessons | 1 Quiz

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Mononuclear Phagocytes Produce Key Inflammatory Cytokines and Chemokines

Dendritic Cells Produce Inflammatory Cytokines and Initiate Adaptive Immunity by Presenting Antigens to T Cells

Mast Cell Mediators Regulate a Variety of Physiological Systems

Watch – The action of mast cells

Basophils and Eosinophils Also Participate in Innate Immunity

Natural Killer Cells Recognize and Kill Virus-Infected Cells

Natural killer T (NKT) cells.

Mucosa-associated invariant T (MAIT) cells

B-1 cells and MZ B cells

Watch – The different killing mechanisms, including NK cells and ADCC

The Innate Immune System Test

MHC & Antigen Presentation 8 Lessons

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MHC Background

MHC Structure and Function

Features of MHC-I and MHC-II molecules

Antigen Presentation

Watch – Antigen Presentation by MHC II

Nomenclature of HLA

Rules that dictate the nomenclature of HLA

Listen – TB Host Directed Therapy and MHC/Antigen Presentation

Overview of T Cell Subsets 9 Lessons

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Introduction – Overview of T Cell Subsets

Lymphocytes Perform Adaptive Immune Functions

Memory T cells

How T cells “see” Antigen

Antigen Processing and Presentation Follows Different Pathways for Cytosolic (Endogenous) and Vesicular (Exogenous) Antigen

The Interaction Between APC and T Cells Influences Which T Cells Are Activated

Watch – T cell and B cell interactions

Th1 Cells Signal Macrophages to Kill Engulfed Intracellular Bacterial Pathogens

Watch – The different killing mechanisms, including CD8 CTL

Thymic T Cell Development 8 Lessons

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Background – Thymic T Cell Development

Central vs. Peripheral Tolerance

Central T-Cell Selection

T cell receptor gene rearrangement

Thymic microenvironment and Thymopoeisis

Central Tolerance generation in the thymus

Research tools for Thymus and T cell development studies

Listen – Tolerance

gamma/delta T Cells 5 Lessons

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Introduction – Unconventional T cells

Unconventional T cells: gamma/delta T cells

Major features of alpha-beta and gamma-delta T cells

Recognition of “phosphoantigens”

Why are gamma/delta T cells of interest for tumor immunotherapy?

B Cell Activation and Plasma Cell Differentiation 4 Lessons

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Activation of B cells

Precursors of plasma cells

The germinal center (GC) reaction

Listen – Germinal centres and tfh cells

Antibody Structure and Classes 7 Lessons

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Immunoglobulin Structure

Biological Functions of Immunoglobulins

The Family of Immunoglobulins Includes Five Functional Classes of Antibodies

Antigen-Independent and Dependent B Cell Development

Somatic Hypermutation and Isotope Class Switch Recombination

B Cell Activation and Antibody Production and the Antigen Antibody Reaction

Listen – ADCC and Antibody functions

Central and Peripheral Tolerance 5 Lessons

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Introduction – Central and Peripheral Tolerance

Central vs. Peripheral Tolerance

Mechanisms of peripheral T-cell tolerance

B-cell Tolerance

Listen – Tolerance